At least eight countries, including Iran, Israel, Jordan and Qatar, have closed their airspace as global air travel has been severely hit.

A wave of America and Israel attack on iranAnd Tehran’s retaliation sparked an outbreak of regional violence that forced the closure of much of the Middle East’s airspace and had repercussions around the world.

When clashes broke out on Saturday, at least eight countries announced airspace closures, including Iran, Israel, Iraq, Jordan, Qatar, Bahrain, Kuwait and the United Arab Emirates. Syria also announced it would close part of its southern border with Israel for 12 hours.

The closure follows the United States and Israel carried out an attack whole iran US President Donald Trump promises would destroy Iran’s missile industry and destroy its navy. Iran was involved Negotiating with the United States over its nuclear program Before the attack, the United States promised a harsh response and soon began launching retaliatory strikes against Israel and several Gulf Arab states that host U.S. military assets, including Qatar, Kuwait, the United Arab Emirates and Bahrain.

“All US and Israeli assets and interests in the Middle East have become legitimate targets,” a senior Iranian official told Al Jazeera. “There are no red lines after this aggression and everything is possible.”

The disruption caused global airlines to cancel or reroute flights from across the Middle East, which has become an important route for flights between Europe and Asia as Russian and Ukrainian airspace is closed to most airlines due to the war.

Russian airlines have suspended flights to Iran and Israel, the Russian Transport Ministry said. Air India said it would avoid the Middle East entirely for the time being.

Other airlines announcing suspensions to destinations in the region include Lufthansa, Air France, Iberia, Wizz Air, Turkish Airlines, Qatar Airways, Virgin Atlantic, KLM, British Airways, Aegean Airlines, IndiGo, Japan Airlines and Scandinavian Airlines.

Al Jazeera’s Ali Hashem reported from Doha that the joint US-Israeli attacks on Iran and Iran’s response have affected many Gulf countries, creating two “parallel” conflicts and further exacerbating instability.

“This could make the entire crisis very intertwined and very complex, something the region has never seen before,” Hashim said.